Please consider the following before referral.
Requirement
Confirmed Alzheimer's diagnosis
Amyloid confirmation (PET or CSF)
Brain MRI using GRE and SWI with ARIA, amyloid imaging abnormality assessment preferable and local access to MRI available such as patient can access the same machine for comparison.
APOE ε4 genotyping status
Baseline bloods, coagulation and renal function to consider.
Any Cardiac issues such as Atrial Fibrillation
MMSE
Care partner identified and engaged
MRI Baseline ARIA eligibility checklist — all preferable to be absent or within acceptable limits:
MRI FindingMacrohemorrhage >1 cm
Microhemorrhages (number: ___)
Superficial siderosis
Cortical infarcts
Lacunar infarcts (number: ___)
Fazekas grade 3 White Matter Disease
Cerebral Amyloid Angiopathy
CAA features
Other major intracranial pathology
No anticoagulant use (or risk formally assessed)
Blood pressure adequately controlled
No recent stroke / TIA (12 months)
No active malignancy
No active or unstable psychiatric disorder
No known serious hypersensitivity to monoclonal antibodies
Non-AD diagnoses excluded (FTD, LBD, vascular dementia)
Renal function acceptable (eGFR: ___)
Unstable arrythmia eg. AF, SVT
APOE STATUS 4/4
Submission of an online referral does not does not automatically constitute acceptance of the referral. We will contact your patient, and you will be advised of the outcome.
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